Effects of pre-emptive pregabalin and multimodal anesthesia on postoperative opioid requirements in patients undergoing robot-assisted laparoscopic prostatectomy

Abstract Background Previous findings indicate that pre-emptive pregabalin as part of multimodal anesthesia reduces opioid requirements compared to conventional in patients undergoing robot-assisted laparoscopic prostatectomy (RALP). However, recent studies show contradictory evidence suggesting does not reduce postoperative pain or consumption after surgeries. We conducted a register-based analysis on RALP treated over 5-year period evaluate between two protocols. Methods retrospectively evaluated years 2015 and 2019. Patients with American Society Anesthesiologists status 1–3, age 30 80 standard were included the study. Pregabalin (PG) group received 150 mg oral premedication before induction, while control (CTRL) was conventionally. Postoperative calculated intravenous morphine equivalent doses for both groups. The impact nausea vomiting (PONV), length stay (LOS) evaluated. Results 245 PG 103 CTRL group. Median (IQR) 24 hours 15 (8–24) 17 (8–25) groups ( p = 0.44). found no difference requirement post care unit, within 12 h postoperatively 0.16; 0.09). unit same each there PONV Similarly, median LOS 31 Conclusion receiving analgesia do need significant amount opioids can be discharged soon procedure. Pre-emptive administration consumption, these patients.